Complete guide on the action mechanism of PDE5 inhibitors

Modern therapy for erectile dysfunction is 99% based on the drug method. The only exceptions are especially severe forms of impotence, in which the only possible way to restore an erection is arthroplasty.

PDE5 inhibitors are used to restore an erection in organic, psychogenic, mixed and drug-induced forms of ED. To date, the FDA and EMA have approved three active ingredients for the treatment of ED: Sildenafil (Viagra), Tadalafil (Cialis) and Vardenafil (Levitra).

The action mechanism of PDE5 inhibitors is physiological and manifests through restoring natural processes in the vessels of the pelvic organs.

Considering the mechanism of pharmacological action in more detail, we see that the drugs of this group help to improve blood circulation in the arterial vessels of the pelvic organs. This happens due to an increase in the content of cGMP in the cells of the vessel walls. With an increase in the concentration of this component, smooth muscle fibers relax, the walls of blood vessels expand and the lumen for blood movement enlarges.

Increased blood circulation leads to blood filling of the cavernous bodies and, which results in a strong erection.

The action of all PDE5 inhibitors is reversible. They work for a certain period and lose their effects once the active substances are excreted from the body (usually within 24 hours). This makes this group of drugs indispensable. Indeed, with such an action, they do not cause irreversible changes, can be used for a long time without restrictions, and do not harm the body even when used daily for 5-10 years.

What effect to expect from Cialis

Cialis is one of the brightest representatives of the PDE5 inhibitor group. The half-life of its active ingredient Tadalafil is 17-19 hours. It takes 36 hours for the drug to lose its properties completely. This indicator is 9 times higher than that of Viagra and 6 times higher than that of Levitra.

At the same time, Cialis is absolutely identical to its analogues in terms of the pharmacological action effectiveness. It also increases blood pressure in the vessels of the penis. If you have never taken Cialis before, we will tell you what you should expect from the use of this drug.

- Within 40 minutes after ingestion, you will feel a rush of blood to the penis. You need to be aroused in order for the drug to work. If you take the pill during the working day, an erection will not appear by itself. Men need stimulation for Tadalafil to begin working.

- During intercourse, lowest price cialis helps maintain a powerful erection so that you do not have to worry about the erection disappearing and getting in an awkward situation. While you're aroused, Tadalafil works.

- Powerful erections and increased blood circulation will enhance the sensation of intimacy and your climax will be brighter.

- After ejaculation, you will need 3 times less recovery time to continue intimacy. It doesn't matter what time it is. Even after the fifth time, Cialis will perform its function and you will be able to continue intercourse. The main thing is that you have enough physical stamina to continue.

- The effect of Cialis lasts 36 hours. You can take the pills at any convenient time and not worry about unexpected intimacy for more than a day. Tadalafil will always help you do your best.

How to take Cialis for the best effect

There is a standard instruction for the use of Cialis that most men follow. However, if you want to achieve a more pronounced therapeutic effect, we have prepared special recommendations and advice. We have studied over 100 blogs, including popular social media. There, men share their life hacks on the use of Cialis. Below, we have prepared the most important findings:

• Cialis works best if you take one 5 mg tablet per day, at the same time, for a long time. You maintain the concentration of Tadalafil at the same level and the body responds better to arousal.
• The 20 mg dose is not beneficial unless you have severe ED. As a rule, it is used in mixed forms, when the cause is both psychogenic and organic form.
• The minimum period of Cialis action is 30 hours. This indicator is not constant. That is, one day you will be ready for action within 36 hours, the other day - 30 hours. It depends on the metabolic processes that take place in your body when you take the pill.
• Take Cialis on an empty stomach. No matter what they say, its activity increases because ultimately more active substances enter the bloodstream.
• If you plan to consume alcohol, do not use the maximum dose. Cialis 5 mg or 10 mg is ideal in this case.

How to reduce the likelihood of side effects

Cialis is one of the safest PDE5 inhibitors. It rarely causes severe side effects and is well tolerated. However, men themselves provoke the body by improper use of the medication. Here are our tips on how to reduce the chance of side effects:

• Do not take Cialis if you have already consumed a large amount of alcohol and are very drunk.
• Do not take Tadalafil if you are using nitroglycerin, organic nitrates, or nitric oxide donors.
• If you have taken other PDE5 inhibitors within the last 24 hours, taking Cialis is contraindicated.
• Do not try to enhance the effect by increasing the dose. If you take 60 mg or 80 mg of Tadalafil, the effect will not improve. Instead, you will have a headache, tachycardia, high blood pressure and other unpleasant symptoms.
• Do not take the tablets with grapefruit juice.
• Do not neglect the advice of a doctor. At the consultation stage, the doctor can identify the peculiarities of your body and prevent side effects. For example, curvature of the penis can lead to priapism. You may not know this, and the doctor will identify the potential danger beforehand.