What is the history and original purpose of viagra?
- Discovery and Development of Viagra by Pfizer
- The Original Purpose: Cardiovascular Problems and PDE-5 Inhibition
- Accidental Finding: Sildenafil and Erectile Dysfunction
- The Role of Sildenafil: Mechanism of Action
- Clinical Trials and FDA Approval
- Viagra's Popularity and Usage Statistics
- Viagra's Transition: Cardiovascular Treatment to Erectile Dysfunction and Recreational Use
- FDA Approval for Pulmonary Arterial Hypertension
- Viagra's Patent History and the Rise of Generic Versions
- What Happens When a Woman Takes Viagra?
- Side Effects of Viagra
- How Long Did It Take for Viagra to Be Approved by the FDA?
- History of the Name 'Viagra'

Discovery and Development of Viagra by Pfizer
The revolutionary drug, Viagra, owes its inception to the global pharmaceutical corporation, Pfizer. The journey of Viagra commenced as an attempt to treat cardiovascular problems, with the compound sildenafil citrate serving as its active ingredient. The primary goal of the development of this compound was the inhibition of the phosphodiesterase-5 (PDE-5) enzyme, which was expected to offer relief to patients with heart complications.
The Original Purpose: Cardiovascular Problems and PDE-5 Inhibition
Contrary to what many may think, Viagra was not originally developed to treat erectile dysfunction. Its initial purpose was to address conditions related to the heart, particularly angina, a condition characterized by chest pain due to reduced blood flow to the heart. Pfizer's researchers believed that sildenafil citrate, as a PDE-5 inhibitor, could enhance blood flow to the heart by dilating the blood vessels. PDE-5 inhibition was considered to be a promising strategy in cardiovascular therapy.
Accidental Finding: Sildenafil and Erectile Dysfunction
During the clinical trials, it was observed that while sildenafil was moderately effective in relieving angina, it had a distinct and pronounced effect on penile erections. Many participants in the trials reported improved and sustained erections. This unintended but beneficial consequence redirected the course of sildenafil's development.
The Role of Sildenafil: Mechanism of Action
The working mechanism of Viagra revolves around enhancing the effect of cyclic guanosine monophosphate (cGMP). Under normal circumstances, the PDE-5 enzyme degrades cGMP in the penis, which is crucial for controlling blood flow. When sildenafil, the main component of Viagra, inhibits the PDE-5 enzyme, it leads to an increase in the concentration of cGMP. Consequently, this increased cGMP causes relaxation and dilation of blood vessels in the penis, enhancing blood flow, which facilitates an erection in response to sexual stimulation.
Clinical Trials and FDA Approval
After this accidental discovery, the focus of the clinical trials shifted to erectile dysfunction, and the development of Viagra took on a new direction. The trials showed substantial evidence of the drug's effectiveness in treating erectile dysfunction. As a result, the US Food and Drug Administration (FDA) approved Viagra for medical use in 1998.
Viagra's Popularity and Usage Statistics
Following its approval, Viagra quickly gained popularity across the globe. Today, it is estimated that the blue pill has been used by over 50 million men worldwide, becoming a ubiquitous name in discussions about sexual health. Its fame extends beyond medical use, with the drug also being used recreationally, especially among young adults.
Viagra's Transition: Cardiovascular Treatment to Erectile Dysfunction and Recreational Use
Originally designed as a treatment for cardiovascular problems, Viagra's trajectory changed significantly after the observation of its effect on erectile dysfunction. Since its launch in 1998, it has revolutionized the treatment of erectile dysfunction, providing a simple and effective option for millions of men. However, it has also seen widespread recreational use, often by individuals without erectile dysfunction, due to its perceived sexual performance-enhancing effects.
FDA Approval for Pulmonary Arterial Hypertension
While its fame for treating erectile dysfunction overshadows other uses, Viagra has not entirely lost its roots in vascular treatment. In 2005, the FDA approved the use of sildenafil under the brand name Revatio for the treatment of pulmonary arterial hypertension, a severe and potentially life-threatening condition characterized by high blood pressure in the arteries leading from the heart to the lungs.
Viagra's Patent History and the Rise of Generic Versions
Pfizer secured a patent for Viagra in 1996, two years before its approval by the FDA. This patent provided them exclusive rights to sell Viagra in the US until 2019. After the patent expired, generic versions of the drug flooded the market, making the medication more accessible and affordable.
What Happens When a Woman Takes Viagra?
Although primarily designed for men, some studies suggest that Viagra might offer some benefits to women, such as alleviating menstrual cramps or treating female sexual arousal disorder. However, the evidence is not robust enough, and the FDA has not approved Viagra for use in women. It is always recommended to consult a healthcare professional before using any medication.
Side Effects of Viagra
Like any medication, Viagra also comes with potential side effects, which can range from mild to severe.
Common side effects include headaches, flushing, upset stomach, abnormal vision, stuffy or runny nose, back pain, muscle pain, and nausea.
Rarely, it may cause an erection that won’t go away (priapism), sudden vision loss in one or both eyes, or sudden hearing decrease or hearing loss.
How Long Did It Take for Viagra to Be Approved by the FDA?
The process from discovery to approval is often lengthy for most medications, and Viagra was no exception. After its initial discovery in the mid-1980s, Viagra went through years of clinical trials before finally receiving FDA approval in 1998.
History of the Name 'Viagra'
The name 'Viagra' does not have a specific meaning. It is thought that the name was coined as a fusion of words. Some suggest it's a combination of 'Vigor' (meaning strength, power) and 'Niagara' (like the powerful Niagara Falls). The moniker perfectly encapsulates the drug's purpose—instilling vitality and power.
Through a fascinating journey of discovery and development, Viagra has significantly impacted the lives of millions around the world, from its roots in cardiovascular treatment to its revolutionary role in managing erectile dysfunction and even its implications in treating other conditions like pulmonary arterial hypertension. However, it's essential to remember that despite its popularity and widespread use, Viagra is a medication that should be used responsibly and under the guidance of a healthcare professional.